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bms
BMS-641988 is a nonsteroidal antiandrogen which was developed by Bristol-Myers Squibb for the treatment of prostate cancer but was never marketed. It acts as a potent competitive antagonist of the androgen receptor (AR) (Ki = 10 nM; IC50 = 56 nM). The drug was found to have 20-fold higher affinity for the AR than bicalutamide in MDA-MB-453 cells, and showed 3- to 7-fold the antiandrogenic activity of bicalutamide in vitro. It may have some weak partial agonist activity at the androgen receptor. BMS-641988 is transformed by CYP3A4 into BMS-570511, and this metabolite is then reduced to BMS-501949 by cytosolic reductases. All three compounds show similar antiandrogenic activity. In addition to its antiandrogenic activity, BMS-641988 shows activity as a negative allosteric modulator of the GABAA receptor, and can produce seizures in animals at sufficiently high doses. It also shows some drug-induced QT prolongation. BMS-641988 reached phase I clinical trials prior to the discontinuation of its development. The clinical development of BMS-641988 was terminated due to the occurrence of a seizure in a patient during a phase I study.
Items i'm using for this battery pack:
1x ~ HX-3S-FL25A-A BMS Balance Charging Board
9x ~ 18650 (3000mAh, 15A Continuous Discharge)
12.6v 2A AC/DC Adapter
Renogy 24V 50Watt Solar Panel
Li-on 12-24V 50A Solar Charge Controller
ISDT 1S-8S Battery Monitor
So when my battery is about 12V, i can see...
Hi.
Thought I'd post to see if I can make contact with someone in the BMS industry.
I'm an electrical tester who is looking to get into the BMS sector. I've tried and tried to get a trainee position, but seem to get pipped at the post and get nowhere!
I am very serious about becoming an...
If you're looking for a career working for one of the strongest, most innovative businesses providing BEMS services across London and the South East then AIS BMS is the company that can help guide and inspire you to achieve your full potential.
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References & current CSCS Card required.
Hi all I have been sent a few jobs to look at and price for BMS installations
What do you charge per point for controls and power? Do you charge more for longer runs IE over 100m.
To be honest am in the deep end here and would like not to come short at the end of it and hopefully gain some...
I’ve been asked to complete somebody else’s BMS install in a school (run & connect cables only). Now I must admit, that this isn’t something that I normally dabble in, but am quite interested in the subject. I’m just after some hints and tips on the subject or anything that might help. Is there...
HiI was wondering if anyone can help me. I need to replace the the fuses for MCB's in a BMS control panel. Can this be done? And how would i go about doing this?Many thanks
Skindy
Thread
bms
canada
control
fuse
fuses
mcb's
panel
replacing
I am looking to change my job, at the moment all the job ads require electricians to have knowledge of Hvac ahu fcu and Bms. Can anybody give me advice as to what course I should take to gain this qualification. I am a 17th edition electrician with C and G 1 and 2. There seems to be no end of...
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